Keck School of Medicine of USC

Collaborative Research

NIH R21 Novel ICA Based Multi-Fiber Streamline Tractography Approach

Principal Investigator
Meng Law, MD, MBBS, FRACR, Professor of Radiology and Neurological Surgery, Director of Neuroradiology, Keck School of Medicine of USC

The goal is to achieve a technological break - through in Diffusion Tensor Imaging (DTI) by enabling accurate multiple-fiber per voxel tractography with clinically acquired data. This will be applied to TBI ad AD.

PROPPR (Pragmatic Randomized Optimum Platelet and Plasma Ratios)

Principal Investigator
Kenji Inaba, MD, FRCSC, FACS, Associate Professor of Surgery and Emergency Medicine, Keck School of Medicine of USC

Kelly Katzberg, MD, FACEP, Assistant Professor of Emergency Medicine, Keck School of Medicine of USC

LAC+USC Departments of Surgery, Anesthesiology and Emergency Medicine are participating in a multi-center RCT looking at massive transfusion protocols. The purpose of the PROPPR study is to learn which combination of blood products given to trauma patients during a Massive Transfusion will improve their survival. The two blood transfusion combinations are: a) 1 unit of red blood cells: 1 unit of plasma: 1 unit of platelets; or b) 2 units of red blood cells: 1 unit of plasma: 1 unit of platelets. Both combinations are in widespread clinical use across the United States.

Effectiveness of Post Stress Glucose in Preventing Dissociative Amnesia and PTSD in Trauma

Principal Investigator
Sean O. Henderson, M.D, FACEP, Professor of Emergency Medicine and Preventive Medicine, Keck School of Medicine of USC

Deirdre Anglin, M.D., MPH, FACEP, Professor of Clinical Emergency Medicine, Keck School of Medicine of USC

Traumatic events alter the manner in which information is processed and memories are consolidated. Psychological dissociation and dissociative amnesia are consequences of this change in information processing. These symptoms are predictive of later, long-term problems with post-traumatic stress disorder (PTSD). Recent research in rats and humans indicates that oral ingestion of glucose following traumatic stress alters the way in which the memory for that event is encoded and dramatically improves the emotional outlook for the individual. This simple manipulation not only eliminates PTSD-like and depression-like symptoms in rats, but also transforms the traumatic experience into a resilience-building exercise. This project is a collaborative effort between University of Southern California (USC) Department of Emergency Medicine, University of California Los Angeles (UCLA) Departments of Psychology and Neuroscience, and Warfighter Performance at the Naval Health Research Center (NHRC) and will determine whether similar benefits accrue from post-stress glucose in human trauma patients recently admitted to USC’s Department of Emergency Medicine. The experiment will use a placebo-controlled, double-blind procedure to determine whether ingestion of glucose within two hours of trauma alleviates dissociative amnesia and subsequent symptoms of PTSD.

USC Adolescent Trauma Training Center (USC-ATTC)

SAMHSA grant # 1U79SM061262-0, 2012-2016, $2.4 million

Center Director
John Briere, Ph.D., Associate Professor of Psychiatry and the Behavioral Sciences and Psychology, University of Southern California

This project creates the University of Southern California Adolescent Trauma Training Center (USC-ATTC), a designated Treatment and Service Adaptation Center of the National Child Traumatic Stress Network (NCTSN). It will train clinicians and disseminate information throughout the United States on the assessment and treatment of trauma effects – including substance abuse -- in multiply-traumatized, socially marginalized adolescents who come in contact with mental health, substance abuse, child welfare, and juvenile justice environments. Through web-based and in-person workshops, USC-ATTC will disseminate the recently developed, empirically-validated Integrative Treatment of Complex Trauma for Adolescents (ITCT-A; Briere & Lanktree, 2011). Additional products of this project will be (1) fact-sheets and other informational products that detail adolescent trauma, its psychological effects, and best-practices for psychological assessment and treatment, (2) a dedicated USC website that will contain information on trauma in adolescents, trauma effects, assessment of adolescent trauma outcomes, a downloadable copy of the ITCT-A treatment manual (2nd edition), and additional resources on adolescent trauma, (3) video-conferencing lectures and workshops on ITCT-A, (4) three types of Learning Communities on ITCT-A, including a train the trainers component, (5) video vignettes demonstrating specific ITCT-A techniques and components, and (6) a list-serve and a NCTSN intranet website where individuals can receive more individualized consultation on adolescent trauma and ITCT-A.


» Anthony Hassan, PhD Clinical Associate Professor and Director, USC Center for Innovation and Research on Veterans and Military Families

» Carlos Pato, MD Chair, Department of Psychiatry

» Emily Putnam-Hornstein, PhD Assistant Professor of Social Work

» Genevieve Santillanes, MD Pediatric Emergency Medicine LAC+USC, Emergency Medicine, Keck School of Medicine

» Ilene Claudius, MD Emergency Medicine, Keck School of Medicine

» Jeffery Wilkins, MD Vice Chair of the Department of Psychiatry and Behavioral Neurosciences at Cedars-Sinai Medical Center

» Jeffrey Victoroff, MD Adjunct Professor and Senior Scientist, USC Center for Innovation and Research on Veterans and Military Families

» Jessica Osterman, MD Assistant Professor of Clinical Emergency Medicine LAC+USC Emergency Medicine

» Kenji Inaba, MD Assistant Professor of Surgery, Department of Acute Care Surgery

» Mike Menchine, MD, MPH Director of Research, Emergency Medicine, University of Southern California

» Peter Gruen, MD Associate Professor of Clinical Neurosurgery

» Sanjay Arora, MD Associate Professor of Clinical Emergency Medicine, Keck School of Medicine

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